WELCOME TO THE KRIMM LAB
A Taste Function and Anatomy Lab at the University of Louisville
The sensations arising from the oral cavity when we eat or drink are complex, involving taste, texture and temperature. The neurons innervating the oral cavity, which carry this information to the brainstem, are poorly understood. We are interested in unraveling anatomy, function, development circuitry, and adult plastic changes of these peripheral neurons. We believe that each student is unique in their experiences, and find that it is important to foster individual growth and development within their academic goals and interests.
TASTE NEURON STRUCTURE AND FUNCTION
We are using a combination of genetic labeling and calcium imaging to examine the relationship between taste neuron structure, function and expression.
TASTE NEURON DEVELOPMENT AND PLASTICITY
For taste neurons the process of connecting with cells in the taste bud is life-long. We are utilizing intra vital imaging to watch this process in the tongue of live animals to determine how this occurs.
ORAL SOMATOSENSORY NEURONS
In addition to taste, food has texture, temperature. We are harnessing genetic labels to determine the structure and function of these neurons and impact taste circuits in the brain.